How does CMI work
Surgeons have known for some time that "more meniscus is better"
and thus aim to preserve or
replace meniscus tissue that is lost to injury, disease, or
surgery. The CMI procedure is a new
way to preserve meniscus tissue volume by encouraging growth of
the patient's own tissue.
The CMI is a biologically, resorbable implant made of highly
purified collagen and was designed
to guide new tissue growth in the meniscus using the body's own
healing process. First, the
CMI is arthroscopically sutured into the void left by a partial
meniscectomy. The CMI provides a
porous scaffold, or template, which the body's own cells
infiltrate. When these cells aggregate
and multiply, they create new meniscus-like tissue. As tissue
generation takes place, the CMI is
gradually rebsorbed by the body.
The new tissue has the potential to restore function, reduce pain,
and possibly delay the
degenerative process that begins with the loss of meniscus
Why Use CMI
- The CMI procedure can help patients avoid permanent loss of
meniscus tissue. Patients treated with CMI are nearly three times
less likely to need additional meniscus surgery compared to
patients treated with only a partial meniscectomy.
- Generation of new tissue in the meniscus may delay or prevent
the development of degenerative joint disease in the knee. In
clinical studies, CMI demonstrated superiority over partial
meniscectomy 10 years post-surgery and has shown the ability to
regenerate up to 75% of the original meniscus.
- Using CMI helps patients with chronic meniscus injuries regain
more of their lost activity levels, than partial meniscectomy
alone. Patients who undergo the CMI procedure have increased
activity levels and decreased pain compared to how they felt prior
- CMI has shown no significant safety issues in clinical studies,
has a 15 year history of clinical use and has been the subject of
more than 20 peer-reviewed publications.
- The procedure can be performed by any surgeon practiced in
arthroscopic surgical techniques for the knee and specifically
trained in the use of the CMI.
Who should receive CMI Therapy?
An orthopedic surgeon is best equipped to determine if a patient
is a good candidate for CMI. Several factors will be assessed,
including (but not limited to):
- Does the patient have an irreparable meniscus tear requiring
- Does the meniscus damage require greater than 25% removal?
- Is the patient willing and able to follow the post-operative
Some patients with certain conditions are not good candidates for
the CMI procedure. This includes those who have:
- PCL insufficiency of the involved knee
- Untreatable degenerative cartilage disease in the affected
- Malformations or malalignment of the knee
- Allergies to animal collagen or chondroitin sulfate
- History of anaphylactoid reaction
- Rheumatoid arthritis
- Relapsing polychondritis
- Degenerative osteoarthritis
- Inflammatory arthritis
For a full listing of product indications, contraindications,
warnings, and precautions click here. Once a doctor determines a
patient is a good candidate for the CMI procedure the steps are
fairly simple. A brief overview of what the patient can expect is
- The surgeon will perform a routine diagnostic arthroscopy to
confirm the meniscus injury and the appropriateness of the CMI
- The surgeon will prepare the meniscus by removing any damaged
- The meniscus defect will be measured, and the CMI scaffold will
be trimmed to fit.
- The CMI scaffold will be placed into the knee joint through an
- The CMI device will be sutured in place.
- The surgeon will close the small openings in the knee that were
used to access the joint space.